CXCR4 Antagonist (GSK812397)

S. Boggs; V. I. Elitzin; K. Gudmundsson; M. T. Martin; M. J. Sharp

doi:10.1055/s-0029-1218261

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Synfacts 2010(1): 0011-0011
DOI: 10.1055/s-0029-1218261

Synthesis of Natural Products and Potential Drugs

CXCR4 Antagonist (GSK812397)

Contributor(s): Philip Kocienski
S. Boggs, V. I. Elitzin*, K. Gudmundsson, M. T. Martin, M. J. Sharp
GlaxoSmithKline, Research Triangle Park, USA

Further Information

Publication History

Publication Date:
21 December 2009 (online)

Permissions and Reprints

Significance

CXC chemokine receptor 4 (CXCR4) is a transmembrane protein that is a host co-receptor for a number of HIV-1 strains. CXCR-4 antagonists could be beneficial in suppressing the replication of late-stage viruses. GSK812397 is a lead for the treatment of HIV infection.