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Synthesis of Cortistatin Analogues
B. Czakó, L. Kürti, A. Mammoto, D. E. Ingber, E. J. Corey*
Harvard University, Cambridge and Harvard Medical School, Boston, USA
20 November 2009 (online)
Cortistatins A and J display significant antiangiogenic activity. Several potent water soluble analogues were synthesized that may be suitable to treat ocular and macular degeneration and related angiogenesis-dependent afflictions. The analogue shown in the scheme exceeds the antiangiogenic potency of cortistatin A in vitro.