Synfacts 2010(1): 0031-0031  
DOI: 10.1055/s-0029-1218460
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart ˙ New York

CuBr-Catalyzed Synthesis of 2-Aminobenzo-thiazoles

Contributor(s): Victor Snieckus, Johnathan Board
S.-S. Pi, X.-G. Zhang, R.-Y. Tang, J.-H. Li*
Wenzhou University, P. R. of China
Further Information

Publication History

Publication Date:
21 December 2009 (online)

Significance

Reported is the copper bromide catalyzed synthesis of 2-aminobenzothiazoles from thiuram disulfides and ortho-halo aniline derivatives. As may be expected, a substoichiometric amount of disulfide is used (0.75 equivalents). The scope of the reaction was adequately tested in terms of aromatic electron-donating and -withdrawing substitution.