Sulfonic Acid Functionalized
Silica: A Mild, Reusable and Efficient Heterogeneous Catalyst
for the Highly Diastereoselective Synthesis of cis-Isoquinolonic
Acids

Ali Reza Karimi; Rahim Pashazadeh

doi:10.1055/s-0029-1218595

PAPER

Sulfonic Acid Functionalized Silica: A Mild, Reusable and Efficient Heterogeneous Catalyst for the Highly Diastereoselective Synthesis of cis-Isoquinolonic Acids

Ali Reza Karimi*, Rahim Pashazadeh
Department of Chemistry, Arak University, Arak 38156, Iran
Fax: +98(861)4173406; e-Mail: a-karimi@araku.ac.ir;

Abstract

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Abstract

Sulfonic acid functionalized silica (SAFS) is found to be a recyclable heterogeneous catalyst for the rapid and efficient synthesis of various cis-isoquinolonic acids from the three-component condensation reaction of homophthalic anhydride, an amine, and an aldehyde. This reaction was highly diastereoselective and only one diastereomer was obtained in all cases.

Key words

sulfonic acid functionalized silica - cis-isoquinolonic acids - diastereoselective synthesis - three-component reaction

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References

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