Abstract
A one-pot, copper-catalyzed method to construct 2-alkynylpyridines
is presented. This provides a route to access these products directly
from terminal alkynes and the parent pyridine, and without prefunctionalization
of the pyridine core. In addition, (Z )-alk-2-enylpyridines
can be prepared via a related procedure. These reactions are used
to synthesize a number of new alkynyl- and alkenyl-substituted
pyridines in one pot.
Key words
pyridine - copper - catalytic - alkyne - alkene
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