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Synthesis 2010(6): 914-916  
DOI: 10.1055/s-0029-1218637
SHORTPAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Facile Synthesis of 3-[(N-Alkylanilino)(aryl)methyl]indoles Using TCT [¹]

Biswanath Das*, Jayprakash Narayan Kumar, Avula Satya Kumar, Kongara Damodar
Organic Chemistry Division-1, Indian Institute of Chemical Technology, Hyderabad 500 007, India
Fax: +91(40)27193198; e-Mail: biswanathdas@yahoo.com;
Further Information

Publication History

Received 17 November 2009
Publication Date:
08 January 2010 (online)

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Abstract

Three component reaction of indoles, benzaldehydes, and N-alkylanilines in the presence of 2,4,6-trichloro-1,3,5-triazine (TCT) afforded the corresponding 3-[(N-alkylanilino)(aryl)methyl]indoles at room temperature in high yields (87-95%) within 1 to 2.5 hours.

Key words

3-[(N-alkylanilino)(aryl)methyl]indoles - benzaldehyde - N-alkylanilines - TCT

1

Part 196 in the series Studies on Novel Synthetic Methodologies.

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1

Part 196 in the series Studies on Novel Synthetic Methodologies.