The Stereoselective Total Synthesis
of (+)-Stagonolide B

Pabbaraja Srihari; Boyapelly Kumaraswamy; Ragam Somaiah; Jhillu S. Yadav

doi:10.1055/s-0029-1218638

PAPER

The Stereoselective Total Synthesis of (+)-Stagonolide B

Pabbaraja Srihari*, Boyapelly Kumaraswamy, Ragam Somaiah, Jhillu S. Yadav
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 607, India
Fax: +91(402)7160512; e-Mail: Srihari@iict.res.in;

Abstract

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Abstract

The stereoselective total synthesis of the nonenolide, (+)-stagonolide B is described. The key steps involve epoxide homologation, hydrolytic kinetic resolution and ring-closing metathesis.

Key words

macrolide - ring-closing metathesis - antifungal - phytotoxic - kinetic resolution

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References

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