Efficient Preparation of Polyfunctional
Organometallics via Directed ortho-Metalation

Stefan H. Wunderlich; Tomke Bresser; Cora Dunst; Gabriel Monzon; Paul Knochel

doi:10.1055/s-0029-1218845

PSP

Efficient Preparation of Polyfunctional Organometallics via Directed ortho-Metalation

Stefan H. Wunderlich, Tomke Bresser, Cora Dunst, Gabriel Monzon, Paul Knochel*
Ludwig-Maximilians-Universität München, Department Chemie und Biochemie, Butenandtstr. 5-13, Haus F, 81377 München, Germany
Fax: +49(89)218077680; e-Mail: paul.knochel@cup.uni-muenchen.de;

Abstract

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Abstract

Highly functionalized organometallics are efficiently prepared in larger quantities (up to 4 g) by directed ortho-metalation using the previously reported amide bases TMP₂Mn˙2MgCl₂˙4LiCl (TMP = 2,2,6,6-tetramethylpiperidyl), TMP₂Fe˙2MgCl₂˙4LiCl and TMP₃La˙3MgCl₂˙5LiCl. The resulting organometallics undergo various reactions with electrophiles like acid chlorides, alkyl iodides, or aldehydes and provide the corresponding products in good to excellent yields.

Key words

directed metalation - organometallics - metal amides - catalysis - LiCl

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References

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