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Synfacts 2010(6): 0663-0663  
DOI: 10.1055/s-0029-1219859
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Gold-Catalyzed γ-Selective Amination of Allylic Alcohols

Contributor(s): Mark Lautens, Stephen G. Newman
P. Mukherjee, R. A. Widenhoefer*
Duke University, Durham, USA
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Publikationsdatum:
20. Mai 2010 (online)

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Significance

Amination of allylic alcohols is an efficient method for the synthesis of useful allyl amines. While examining intermolecular hydro­amination chemistry, the authors discovered a highly γ-selective allylation of amines utilizing a cationic gold(I) catalyst.