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Dtsch Med Wochenschr 2009; 134(25/26): 1357-1360
DOI: 10.1055/s-0029-1225291
Klinischer Fortschritt | Commentary

© Georg Thieme Verlag KG Stuttgart · New York

Neurologie 2009

Neurology 2009A. Straube1
  • 1Klinik für Neurologie, Standort Großhadern, Universität München
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Publication History

Publication Date:
10 June 2009 (online)

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Was ist neu?

  • Zerebrovaskuläre Erkrankungen:Telemedizinische Vorstellung bei Schlaganfall in überregionalen Versorgungszentren kann die Qualität der medizinischen Versorgung verbessern; systemische Thrombolyse bei ischämischen Schlaganfällen bis zu 4,5 h nach Symptombeginn wirksam; konsequente Hochdrucktherapie hilft, Schlaganfälle auch bei Hochbetagten zu verhindern, nicht aber die Entstehung einer Demenz.

  • Neuro-degenerative Erkrankungen: Tiefe Hirnstimulation bei einem idiopathischem Parkinson-Syndrom der bestmöglichen Pharmakotherapie überlegen, Patienten müssen aber auf Zeichen einer Depressivität beobachtet werden; körperliche Übungsprogramme können möglicherweise den Verlauf einer dementiellen Erkrankung positiv beeinflussen.

  • Kopfschmerz: CGRP-Antagonisten als neueSubstanzklasse in der Migränetherapie.

  • Neuropathische Schmerzen: „Small-Fiber-Neuropathien” lassen sich nicht mit den klassischen Verfahren der Elektrophysiologie untersuchen, die Qualitative Sensorische Testung (QST) ermöglicht dabei eine standardisierte Untersuchung.

Literatur

  • 1 Aisen P S, Schneider L S, Sano M. et al . Alzheimer Disease Cooperative Study. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial.  JAMA. 2008;  300 1774-1783
    Google Scholar
  • 2 Beckett N S, Peters R, Fletcher A E. et al, HYVET Study Group . Treatment of hypertension in patients 80 years of age or older.  N Engl J Med. 2008;  358 1887-1898
    Google Scholar
  • 3 Crofford L J, Mease P J, Simpson S L. et al . Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): a 6-month, double-blind, placebo-controlled trial with pregabalin.  Pain. 2008;  136 419-431
    Google Scholar
  • 4 Dehning S, Mehrkens J H, Müller N, Bötzel K. Therapy-refractory Tourette syndrome: beneficial outcome with globus pallidus internus deep brain stimulation.  Mov Disord. 2008;  23 1300-1302
    Google Scholar
  • 5 Devigili G, Tugnoli V, Penza P. et al . The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology.  Brain. 2008;  131 1912-1925
    Google Scholar
  • 6 Diener H C, Sacco R L, Yusuf S. et al, Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study group . Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study.  Lancet Neurol. 2008;  7 875-884
    Google Scholar
  • 7 Greenberg B D, Malone D A, Friehs G M. et al . Three-year outcomes in deep brain stimulation for highly resistant obsessive-compulsive disorder.  Neuropsychopharmacology. 2006;  31 2384-2393
    Google Scholar
  • 8 Hacke W, Kaste M, Bluhmki E. et al, ECASS Investigators . Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke.  N Engl J Med. 2008;  359 1317-1329
    Google Scholar
  • 9 Ho T W, Ferrari M D, Dodick D W. et al . Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial.  Lancet. 2008;  372 2115-2123
    Google Scholar
  • 10 Johnson K C, Margolis K L, Espeland M A. et al, Women’s Health Initiative Memory Study and Women’s Health Initiative Investigators . A prospective study of the effect of hypertension and baseline blood pressure on cognitive decline and dementia in postmenopausal women: the Women’s Health Initiative Memory Study.  J Am Geriatr Soc. 2008;  56 1449-1458
    Google Scholar
  • 11 Kuhn J, Lenartz D, Huff W. et al . Remission of alcohol dependency following deep brain stimulation of the nucleus accumbens: valuable therapeutic implications?.  J Neurol Neurosurg Psychiatry. 2007;  78 1152-1153
    Google Scholar
  • 12 Kuhn J, Lenartz D, Mai J K. et al . Disappearance of self-aggressive behavior in a brain-injured patient after deep brain stimulation of the hypothalamus: technical case report.  Neurosurgery. 2008;  62 E1182
    Google Scholar
  • 13 Lautenschlager N T, Cox K L, Flicker L. et al . Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial.  JAMA. 2008;  300 1027-1037
    Google Scholar
  • 14 Meyer B C, Raman R, Hemmen T. et al . Efficacy of site-independent telemedicine in the STRokE DOC trial: a randomised, blinded, prospective study.  Lancet Neurol. 2008;  7 787-795
    Google Scholar
  • 15 Peters R, Beckett N, Forette F. et al, HYVET investigators . Incident dementia and blood pressure lowering in the hypertension in the very elderly trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial.  Lancet Neurol. 2008;  7 683-689
    Google Scholar
  • 16 Pfaffenrath V, Fendrich K, Vennemann M. et al . Regional variations in the prevalence of migraine and tension-type headache applying the new IHS criteria: the German DMKG Headache Study.  Cephalalgia. 2009;  29 48-57
    Google Scholar
  • 17 Rolke R, Baron R, Maier C. et al . Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values.  Pain. 2006;  123 231-243
    Google Scholar
  • 18 Rundek T, Elkind M S, Di Tullio M R. et al . Patent foramen ovale and migraine: a cross-sectional study from the Northern Manhattan Study (NOMAS).  Circulation. 2008;  118 1419-1424
    Google Scholar
  • 19 Schlaepfer T E, Cohen M X, Frick C. et al . Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression.  Neuropsychopharmacology. 2008;  33 368-377
    Google Scholar
  • 20 Servello D, Porta M, Sassi M. et al . Deep brain stimulation in 18 patients with severe Gilles de la Tourette syndrome refractory to treatment: the surgery and stimulation.  J Neurol Neurosurg Psychiatry. 2008;  79 136-142
    Google Scholar
  • 21 Sillberg V A, Wells G A, Perry J J. Do statins improve outcomes and reduce the incidence of vasospasm after aneurysmal subarachnoid hemorrhage: a meta-analysis.  Stroke. 2008;  39 2622-2626
    Google Scholar
  • 22 Soulas T, Gurruchaga J M, Palfi S. et al . Attempted and completed suicides after subthalamic nucleus stimulation for Parkinson’s disease.  J Neurol Neurosurg Psychiatry. 2008;  79 851-855
    Google Scholar
  • 23 Temel Y, Boothman L J, Blokland A. et al . Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus.  Proc Natl Acad Sci U S A. 2007;  104 17087-17092
    Google Scholar
  • 24 Weaver F M, Follett K, Stern M. et al, CSP 468 Study Group . Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial.  JAMA. 2009;  301 63-73
    Google Scholar
  • 25 Wedderburn C J, van Beijnum J, Bhattacharya J J. et al, SIVMS Collaborators . Outcome after interventional or conservative management of unruptured brain arteriovenous malformations: a prospective, population-based cohort study.  Lancet Neurol. 2008;  7 223-230
    Google Scholar
  • 26 Witt K, Daniels C, Reiff J. et al . Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson’s disease: a randomised, multicentre study.  Lancet Neurol. 2008;  7 605-614
    Google Scholar

Prof. Dr. med. Andreas Straube

Klinik für Neurologie, Standort Großhadern, Universität München

Marchioninistraße 15

81366 München

Phone: 089/7095-3901

Fax: 089/7095-3677

Email: astraube@nefo.med.uni-muenchen.de

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