DMW - Deutsche Medizinische Wochenschrift, Inhaltsverzeichnis Dtsch Med Wochenschr 2009; 134(37): 1835-1837DOI: 10.1055/s-0029-1237522 Kommentar | CommentaryGastroenterologie, Onkologie© Georg Thieme Verlag KG Stuttgart · New YorkNeoadjuvante Therapien bei gastrointestinalen Tumoren: Müssen wir umdenken?The neoadjuvant treatment of gastrointestinal tumors: time for rethinking?M. P. Ebert1 , R. M. Schmid1 1II. Medizinische Klinik des Klinikums rechts der Isar, Technische Universität München Artikel empfehlen Abstract Artikel einzeln kaufen(opens in new window) Schlüsselwörter neoadjuvante Therapie - Chemotherapie - Radiochemotherapie - Ösophaguskarzinom - Magenkarzinom - Pankreaskarzinom - Rektumkarzinom Keywords neoadjuvant therapy - chemotherapy - radiochemotherapy - gastric cancer - oesophageal cancer - pancreatic cancer - rectal cancer Volltext Referenzen Literatur 1 Bedenne L, Michel P, Bouché O. et al . Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102. J Clin Oncol. 2007; 25 1160-1168 2 Boige V, Pignon J, Saint-Aubert B. et al . Final results of a randomized trial comparing preoperative 5-fluorouracil (F)/cisplatin (P) to surgery alone in adenocarcinoma of stomach and lower esophagus (ASLE). J Clin Oncol. 2007; 25 18S 3 Bosset J F, Gignoux M, Triboulet J P. et al . Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus. N Engl J Med. 1997; 337 161-167 4 Burmeister B H, Smithers B M, Gebski V. et al . Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus. Lancet Oncol. 2005; 6 659-668 5 Chauffert B, Mornex F, Bonnetain F. et al . Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Ann Oncol. 2008; 19 1592-1599 6 Cunningham D, Allum W H, Stenning S P. et al . Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 2006; 355 11-20 7 Imamura M, Doi R, Imaizumi T. et al . A randomized multicenter trial comparing resection and radiochemotherapy for resectable locally invasive pancreatic cancer. Surgery. 2004; 136 1003-1011 8 Palmer D H, Stocken D D, Hewitt H. et al . A randomized phase 2 trial of neoadjuvant chemotherapy in resectable pancreatic cancer: gemcitabine alone versus gemcitabine combined with cisplatin. Ann Surg Oncol. 2007; 14 2088-2096 9 Sauer R, Becker H, Hohenberger W. et al . Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004; 351 1731-1740 10 Stahl M, Stuschke M, Lehmann N. et al . Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus. J Clin Oncol. 2005; 23 2310-2317 11 Stahl M, Walz M K, Stuschke M. et al . Phase III comparison of preoperative chemotherapy compared with chemoradiotherapy in patients with locally advanced adenocarcinoma of the esophagogastric junction. J Clin Oncol. 2009; 27 851-856 12 Witzigmann H, Berr F, Ringel U. et al . Surgical and palliative management and outcome in 184 patients with hilar cholangiocarcinoma. Ann Surg. 2006; 244 230-239 Prof. Dr. M. Ebert II. Medizinische Klinik des Klinikums rechts der Isar, Technische Universität München Ismaninger Str. 22 81675 München Telefon: 089/4140-4386 Fax: 089/4140-4115 eMail: Matthias.Ebert@lrz.tum.de