Semin Liver Dis 2009; 29(4): 393-399
DOI: 10.1055/s-0029-1240008
© Thieme Medical Publishers

Biomarkers for the Diagnosis and Management of Drug-Induced Liver Injury

Paul B. Watkins1 , 2
  • 1Verne S. Caviness Distinguished Professor of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
  • 2Director, The Hamner–UNC Institute for Drug Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina
Further Information

Publication History

Publication Date:
13 October 2009 (online)

ABSTRACT

There is a pressing need for new clinical tests that will help physicians distinguish drug-induced liver injury (DILI) from other, more common causes of liver injury, and that can identify which specific drug is the culprit when DILI occurs in the setting of polypharmacy. In situations where there are few alternative treatments, new tests are needed that can differentiate patients with DILI who would develop progressive liver injury if treatment is not stopped from patients who can safely continue drug therapy via “adaptation.” Although there has been little progress in developing and validating such tests, new insights into the mechanisms underlying DILI suggest that the desired biomarkers probably exist and can be discovered through the application of new technologies for blood and possibly urine analyses. Such discovery efforts will require the establishment of well-annotated serum and urine banks from prospective clinical trials of drugs capable of causing progressive liver injury.

REFERENCES

Paul B Watkins, M.D. 

Director, The Hamner–UNC Institute for Drug Safety Sciences, The Hamner Institutes for Health Sciences

Six Davis Drive, P.O. Box 12137, Research Triangle Park, NC 27709

Email: pbwatkins@med.unc.edu