Laryngorhinootologie 2009; 88(10): 666-675
DOI: 10.1055/s-0029-1241184
CME-Fortbildung

© Georg Thieme Verlag KG Stuttgart · New York

Leukoplakie und Erythroplakie – Zwei orale Präkursorläsionen

Leukoplakia and Erythroplakia – Two Orale Precursor LesionsS. Grajewski1 , D. Groneberg1
  • 1Institut für Arbeitsmedizin, Charité – Universitätsmedizin Berlin (Direktor: Univ.-Prof. Dr. D. Groneberg)
Further Information

Publication History

Publication Date:
07 October 2009 (online)

Zusammenfassung

Die orale Leukoplakie/Erythroplakie gehört zu den häufigsten epithelialen Präkursorläsionen des oralen Plattenepithelkarzinoms. Klinisch unterscheidet man homogene und nicht homogene Leukoplakien sowie die proliferative verruköse Leukoplakie und die Erythroplakie. Aufgrund der schlechten Prognose des oralen Plattenepithelkarzinoms ist es von großer Bedeutung, Morbidität und Mortalität durch die gezielte Primär-, Sekundär- und Tertiärprävention der Leukoplakie/Erythroplakie zu verringern. Anhand von histologischen Klassifikationssystemen lässt sich das Risiko der malignen Transformation abschätzen, eine definierte Therapie einleiten und Prognosen ableiten.

Abstract

The oral leukoplakia/erythroplakia is one of the most common epithelial precursor lesions of the oral squamous cell carcinoma. A clinical distinction is drawn between homogeneous and non-homogeneous as well as proliferative verrucous leukoplakia and erythroplakia. Due to the fact that the oral squamous cell carcinoma has a poor prognosis it is very important to decrease morbidity and mortality by systematic primary, secondary and tertiary prevention of the oral leukoplakia/erythroplakia. On the basis of histological classification systems the risk of malignant transformation can be evaluated, a defined therapy can be induced and the prognosis can be derived.

Literatur

  • 1 WHO . Definition of leukoplakia and related lesions: An aid to studies on oral cancer: An aid to studies on oral precancer.  Oral Surg Oral Med Oral Pathol. 1978;  46 518-539
  • 2 Gale N, Pilch BZ, Sidransky D. et al .eds. Epithelial precursor lesions. Lyon: International Agency for Research on Cancer (IARC) Press 2005: 177-179
  • 3 Driemel O, Hertel K, Reichert TE. et al . Current classification of precursor lesions of oral squamous cell carcinoma principles of the WHO classification 2005.  Mund Kiefer Gesichtschir. 2006;  10 89-93
  • 4 Gale N, Pilch BZ, Sidransky D. et al .eds. Epithelial precursor lesions. Lyon: IARC Press 2005: 140-143
  • 5 Scheifele C, Reichart PA, Dietrich T. Low prevalence of oral leukoplakia in a representative sample of the US population.  Oral Oncol. 2003;  39 619-625
  • 6 Reichart PA. Oral mucosal lesions in a representative cross-sectional study of aging Germans.  Community Dent Oral Epidemiol. 2000;  28 390-398
  • 7 Gupta PC, Mehta FS, Daftary DK. et al . Incidence rates of oral cancer and natural history of oral precancerous lesions in a 10-year follow-up study of Indian villagers.  Community Dent Oral Epidemiol. 1980;  8 283-333
  • 8 Nagao T, Ikeda N, Fukano H. et al . Incidence rates for oral leukoplakia and lichen planus in a Japanese population.  J Oral Pathol Med. 2005;  34 532-539
  • 9 Speight PM, Farthing PM, Bouquot JE. The pathology of oral cancer and precancer.  Current Diagnostic Pathology. 1996;  3 165-176
  • 10 Napier SS, Speight PM. Natural history of potentially malignant oral lesions and conditions: An overview of the literature.  J Oral Pathol Med. 2008;  37 1-10
  • 11 Reichart PA. Identification of risk groups for oral precancer and cancer and preventive measures.  Clin Oral Investig. 2001;  5 207-213
  • 12 Ha PK, Califano JA. The role of human papillomavirus in oral carcinogenesis.  Crit Rev Oral Biol Med. 2004;  15 188-196
  • 13 Squier CA, Cox P, Hall BK. Enhanced penetration of nitrosonornicotine across oral mucosa in the presence of ethanol.  J Oral Pathol. 1986;  15 276-279
  • 14 van der Waal I, Axell T. Oral leukoplakia: a proposal for uniform reporting.  Oral Oncol. 2002;  38 521-526
  • 15 Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa.  J Oral Pathol Med. 2007;  36 575-580
  • 16 Reichart PA, Philipsen HP. Oral erythroplakia – a review.  Oral Oncol. 2005;  41 551-561
  • 17 Lodi G, Sardella A, Bez C. et al . Interventions for treating oral leukoplakia.  Cochrane Database Syst Rev. 2006;  CD001829
  • 18 Hansen LS, Olson JA, Silverman Jr. S. Proliferative verrucous leukoplakia. A long-term study of thirty patients.  Oral Surg Oral Med Oral Pathol. 1985;  60 285-298
  • 19 Batsakis JG, Suarez P, el-Naggar AK. Proliferative verrucous leukoplakia and its related lesions.  Oral Oncol. 1999;  35 354-359
  • 20 Greer RO. Pathology of malignant and premalignant oral epithelial lesions.  Otolaryngol Clin North Am. 2006;  39 249v-275v
  • 21 Reichart PA, Philipsen HP. Proliferative verrucous leukoplakia. Report of five cases.  Mund Kiefer Gesichtschir. 2003;  7 164-170
  • 22 Neid M, Tannapfel A. Squamous intraepithelial neoplasia (WHO 2005). Precancerous lesions of the head and neck region.  HNO. 2009;  57 181-187 quiz 188 
  • 23 Kambic V, Lenart I. Our classification of hyperplasia of the laryngeal epithelium from the prognostic point of view.  J Fr Otorhinolaryngol Audiophonol Chir Maxillofac. 1971;  20 1145-1150
  • 24 Scully C, Porter S. ABC of oral health. Oral cancer.  BMJ (Clinical research ed). 2000;  321 97-100
  • 25 Lodi G, Porter S. Management of potentially malignant disorders: evidence and critique.  J Oral Pathol Med. 2008;  37 63-69
  • 26 Reichart PA. Primary prevention of mouth carcinoma and oral precancerous conditions.  Mund Kiefer Gesichtschir. 2000;  4 357-364
  • 27 El Naggar AK P. A. R .Proliferative verrucous leukoplakia and precancerous conditions. Lyon: International Agency for Research on Cancer (IARC) Press 2005: 430
  • 28 Silverman S, Gorsky M. Proliferative verrucous leukoplakia: A follow-up study of 54 cases.  Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;  84 154-157

Korrespondenzadresse

Dr. Sonja Grajewski

Institut für Arbeitsmedizin

Thielallee 69–73

14159 Berlin

Email: sonja.grajewski@charite.de