Bluthochdruck und sympathisches Nervensystem – neue Entwicklungen in Forschung und Therapie

Zusammenfassung

Das sympathische Nervensystem ist wesentlich an der Kreislaufregulation beteiligt und bietet pharmakotherapeutische und nicht-pharmakologische Interventionsmöglichkeiten zur Behandlung der arteriellen Hypertonie. Aktuelle Forschungsergebnisse zur Organisation der Adrenorezeptoren in Multiproteinkomplexen haben unsere Kenntnisse zur Blutdruckregulation erweitert und können der pharmakologischen und genetischen Forschung auf dem Gebiet der Hypertensiologie neue Impulse verleihen. Neue Entwicklungen der biomedizinischen Technik ermöglichen nicht-pharmakologische sympathikolytische Interventionen, die insbesondere bei pharmakotherapieresistenten Hypertonieformen die Behandlungsmöglichkeiten erweitern.

Summary

The sympathetic nervous system importantly contributes to the control of the circulation and is an important therapeutic target to lower arterial pressure in hypertensive patients. Recent advances in the understanding of the organization of adrenergic receptors in multiprotein complexes have improved our understanding of arterial pressure control and may have impact on drug development and genetic research in the field of hypertension. New developments in biomedical technology allow for non-pharmacological interventions to reduce sympathetic activity and provide new options to treat hypertensive patients who are resistant to antihypertensive drug therapy.

arterielle Hypertonie - Antihypertonika - Sympathikusaktivierung

arterial hypertension - antihypertensive drugs - sympathetic activation

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