Facial Plast Surg 2009; 25(4): 270-276
DOI: 10.1055/s-0029-1242033
© Thieme Medical Publishers

Applications of Platelet-Rich Fibrin Matrix in Facial Plastic Surgery

Anthony P. Sclafani1
  • 1Director of Facial Plastic Surgery, The New York Eye and Ear Infirmary, New York, New York; and Professor of Otolaryngology, New York Medical College, Valhalla, New York
Further Information

Publication History

Publication Date:
18 November 2009 (online)

ABSTRACT

Platelet concentrates enjoyed some clinical popularity in facial plastic surgery several years ago. However, interest waned due to expense, amount of blood required, equipment, space, and staff needed, and lack of clinically significant benefit. A novel, simple method of preparing an autologous platelet derivative (Selphyl; Aesthetic Factors, Princeton, NJ) allows rapid and inexpensive generation of a platelet-rich fibrin matrix (PRFM) that can be used to enhance healing after facial procedures as well as to rejuvenate the face without tissue manipulation. PRFM provides autologous, natural, but concentrated platelet growth factor release and stimulation of surrounding tissue. This article describes its use for cosmetic facial applications.

REFERENCES

  • 1 Hom D B. New developments in wound healing relevant to facial plastic surgery.  Arch Facial Plast Surg. 2008;  10 402-406
  • 2 Kakudo N, Minakata T, Mitsui T, Kushida S, Notodihardjo F Z, Kusumoto K. Proliferation-promoting effect of platelet-rich plasma on human adipose-derived stem cells and human dermal fibroblasts.  Plast Reconstr Surg. 2008;  122 1352-1360
  • 3 Choi B H, Zhu S J, Kim B Y, Huh J Y, Lee S H, Jung J H. Effect of platelet-rich plasma (PRP) concentration on the viability and proliferation of alveolar bone cells: an in vitro study.  Int J Oral Maxillofac Surg. 2005;  34 420-424
  • 4 Sclafani A P, Romo III T, Ukrainsky G et al.. Modulation of wound response and soft tissue ingrowth in synthetic and allogeneic implants with platelet concentrate.  Arch Facial Plast Surg. 2005;  7 163-169
  • 5 Hom D B, Linzie B M, Huang T C. The healing effects of autologous platelet gel on acute human skin wounds.  Arch Facial Plast Surg. 2007;  9 174-183
  • 6 Powell D M, Chang E, Farrior E H. Recovery from deep-plane rhytidectomy following unilateral wound treatment with autologous platelet gel: a pilot study.  Arch Facial Plast Surg. 2001;  3 245-250
  • 7 Danielsen P, Jørgensen B, Karlsmark T, Jorgensen L N, Agren M S. Effect of topical autologous platelet-rich fibrin versus no intervention on epithelialization of donor sites and meshed split-thickness skin autografts: a randomized clinical trial.  Plast Reconstr Surg. 2008;  122 1431-1440
  • 8 Anitua E, Sanchez M, Nurden A T et al.. Autologous fibrin matrices: a potential source of biological mediators that modulate tendon cell activities.  J Biomed Mater Res. 2006;  77A 285-293
  • 9 Torio-Padron N, Baerlecken N, Momeni A, Stark G B, Borges J. Engineering of adipose tissue by injection of human preadipocytes in fibrin.  Aesthetic Plast Surg. 2007;  31 285-293
  • 10 Schoeller T, Lille S, Wechselberger G et al.. Histomorphologic and volumetric analysis of implanted autologous preadipocyte cultures suspended in fibrin glue: a potential new source for tissue augmentation.  Aesthetic Plast Surg. 2001;  25 57-63
  • 11 Azzena B, Mazzoleni F, Abatangelo G, Zavan B, Vindigni V. Autologous platelet-rich plasma as an adipocyte in vivo delivery system: case report.  Aesthetic Plast Surg. 2008;  32 155-158 discussion 159-161
  • 12 Cervelli V, Gentile P. Use of platelet gel in Romberg syndrome.  Plast Reconstr Surg. 2009;  123 22e-23e
  • 13 Nitche J, Greco S, Merriam A et al.. Platelet rich fibrin matrix to enhance periarticular tendon to bone healing. Presented at: The American Orthopedic Society for Sports Medicine 2008 Annual Meeting July 10–13, 2008 Orlando, FL;
  • 14 Sánchez M, Anitua E, Azofra J, Andía I, Padilla S, Mujika I. Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices.  Am J Sports Med. 2007;  35 245-251
  • 15 Fanelli G C, Edson C J, Reinheimer K N. Surgical technique: surgeon details pearls for two PCL reconstruction methods.  Orthoped Today. 2007;  27 1-5
  • 16 O’Connell S M, Impeduglia T, Hessler K, Wang X-J, Carroll R J, Dardik H. Autologous platelet-rich fibrin matrix as cell therapy in the healing of chronic lower-extremity ulcers.  Wound Repair Regen. 2008;  16 749-756
  • 17 Carroll R J, Arnoczky S P, Graham S, O'Connell S M. Characterization of autologous growth factors in Cascade® platelet-rich fibrin matrix (PRFM). Edison, NJ; Musculoskeletal Transplant Foundation 2005 128-XM 307C5
  • 18 O’Connell S M, Carroll R J, Beavis A, Arnoczky S P. Flow cytometric characterization of Cascade® platelet-rich fibrin matrix (PRFM): the impact of exogenous thrombin of platelet concentrates (PC). Edison, NJ; Musculoskeletal Transplant Foundation 2006 128-2.5M 406TC1
  • 19 Sclafani A P. Platelet rich fibrin matrix for improvement of deep nasolabial folds. Presented at: The Annual Meeting of the Triological Society May 28–30, 2009 Scottsdale, AZ;

Anthony P SclafaniM.D. F.A.C.S. 

Director of Facial Plastic Surgery, The New York Eye and Ear Infirmary

310 East 14th Street, Sixth Floor, North Building, New York, NY 10003

Email: asclafani@nyee.edu

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