ABSTRACT
Patients who experience frequent exacerbations of chronic obstructive pulmonary disease
(COPD) are known to have a higher mortality, reduced exercise capacity, and muscle
atrophy. The next key challenges for the implementation of effective pulmonary rehabilitation
are to reverse these changes and enable patients to recover from an exacerbation without
serial decline in their functional capacity with each subsequent exacerbation. Current
evidence suggests that early rehabilitation following an exacerbation may prove beneficial,
although this has been described in a variety of guises and needs further evidence
to identify the exact form that it should take. Other additional interventions such
as the use of noninvasive ventilation, quadriceps muscle training, early ambulation
with rollator frames, and inspiratory muscle training have been shown to demonstrate
positive outcomes in these patients and may well complement outcomes achieved through
early pulmonary rehabilitation programs. It is clear that further research into early
pulmonary rehabilitation is required to identify the point at which it should start,
what form it should take, how long programs should be to produce positive outcomes,
and what the inclusion and exclusion criteria should be.
KEYWORDS
Early pulmonary rehabilitation - inspiratory muscle training - leg atrophy - noninvasive
ventilation
REFERENCES
- 1
Lacasse Y, Goldstein R, Lasserson T J, Martin S.
Pulmonary rehabilitation for chronic obstructive pulmonary disease.
Cochrane Database Syst Rev.
2006;
(4)
CD003793
- 2 Trikalinos T A, Raman G, Kupelnick B et al.. Pulmonary Rehabilitation for COPD and
Other Lung Diseases. Technology Assessment. Prepared by the Tufts–New England Medical
Centre Evidence-Based Practice Centre for the Agency of Healthcare Research and Quality
Rockville, MD; AHRQ 2006
- 3 Chartered Society of Physiotherapy .The effectiveness of pulmonary rehabilitation:
evidence and implications for physiotherapists. 2003. Available at: http://www.csp.org.ukwww.csp.org.uk
- 4
Griffiths T L, Burr M L, Campbell I A et al..
Results at 1 year of outpatient multidisciplinary pulmonary rehabilitation: a randomised
controlled trial.
Lancet.
2000;
355
362-368
- 5
Griffiths T L, Phillips C J, Davies S, Burr M L, Campbell I A.
Cost effectiveness of an outpatient multidisciplinary pulmonary rehabilitation programme.
Thorax.
2001;
56
779-784
- 6
Golmohammadi K, Jacobs P, Sin D D.
Economic evaluation of a community-based pulmonary rehabilitation program for chronic
obstructive pulmonary disease.
Lung.
2004;
182
187-196
- 7
California Pulmonary Rehabilitation Collaborative Group .
Effects of pulmonary rehabilitation on dyspnea, quality of life, and healthcare costs
in California.
J Cardiopulm Rehabil.
2004;
24
52-62
- 8
Wedzicha J A, Bestall J, Garnham R, Garrod R, Paul E A, Jones P W.
Randomized controlled trial of pulmonary rehabilitation in severe chronic obstructive
pulmonary disease patients, stratified with the MRC dyspnoea scale.
Eur Respir J.
1998;
12
363-369
- 9
Wedzicha J A, Seemungal T AR.
COPD exacerbations: defining their cause and prevention.
Lancet.
2007;
370
786-796
- 10
Seemungal T AR, Donaldson G C, Bhowmik A, Jeffries D J, Wedzicha J A.
Time course and recovery of exacerbations in patients with chronic obstructive pulmonary
disease.
Am J Respir Crit Care Med.
2000;
161
1608-1613
- 11
Hurst J R, Donaldson G C, Quint J K, Goldring J JP, Baghai-Ravary R, Wedzicha J A.
Temporal clustering of exacerbations in chronic obstructive pulmonary disease.
Am J Respir Crit Care Med.
2009;
179
369-374
- 12
Seemungal T AR, Donaldson G C, Paul E A, Bestall J C, Jeffries D J, Wedzicha J A.
Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary
disease.
Am J Respir Crit Care Med.
1998;
157
1418-1422
- 13
Burge S, Wedzicha J A.
COPD exacerbations: definitions and classifications.
Eur Respir J.
2003;
41
46s-53s
- 14
Donaldson G C, Seemungal T AR, Bhowmik A, Wedzicha J A.
Relationship between exacerbation frequency and lung function decline in chronic obstructive
pulmonary disease.
Thorax.
2002;
57
847-852
- 15
Soler-Cataluña J J, Martínez-García M A, Román Sánchez P, Salcedo E, Navarro M, Ochando R.
Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary
disease.
Thorax.
2005;
60
925-931
- 16
Donaldson G C, Wilkinson T MA, Hurst J R, Perera W R, Wedzicha J A.
Exacerbations and time spent outdoors in chronic obstructive pulmonary disease.
Am J Respir Crit Care Med.
2005;
171
446-452
- 17
Hamilton A L, Killian K J, Summers E, Jones N L.
Muscle strength, symptom intensity, and exercise capacity in patients with cardiorespiratory
disorders.
Am J Respir Crit Care Med.
1995;
152(6 Pt 1)
2021-2031
- 18
Bernard S, LeBlanc P, Whittom F et al..
Peripheral muscle weakness in patients with chronic obstructive pulmonary disease.
Am J Respir Crit Care Med.
1998;
158
629-634
- 19
Gosselink R, Troosters T, Decramer M.
Peripheral muscle weakness contributes to exercise limitation in COPD.
Am J Respir Crit Care Med.
1996;
153
976-980
- 20
Swallow E B, Reyes D, Hopkinson N S et al..
Quadriceps strength predicts mortality in patients with moderate to severe chronic
obstructive pulmonary disease.
Thorax.
2007;
62
115-120
- 21
Schols A M, Broekhuizen R, Weling-Scheepers C A, Wouters E F.
Body composition and mortality in chronic obstructive pulmonary disease.
Am J Clin Nutr.
2005;
82
53-59
- 22
Marquis K, Debigaré R, Lacasse Y et al..
Midthigh muscle cross-sectional area is a better predictor of mortality than body
mass index in patients with chronic obstructive pulmonary disease.
Am J Respir Crit Care Med.
2002;
166
809-813
- 23
Mostert R, Goris A, Weling-Scheepers C A, Wouters E F, Schols A M.
Tissue depletion and health related quality of life in patients with chronic obstructive
pulmonary disease.
Respir Med.
2000;
94
859-867
- 24
Spruit M A, Gosselink R, Troosters T et al..
Muscle force during an acute exacerbation in hospitalised patients with COPD and its
relationship with CXCL8 and IGF-I.
Thorax.
2003;
58
752-756
- 25
Crul T, Spruit M A, Gayan-Ramirez G et al..
Markers of inflammation and disuse in vastus lateralis of chronic obstructive pulmonary
disease patients.
Eur J Clin Invest.
2007;
37
897-904
- 26
Martínez-Llorens J M, Orozco-Levi M, Masdeu M J et al..
Global muscle dysfunction and exacerbation of COPD: a cohort study [in Spanish].
Med Clin (Barc).
2004;
122
521-527
- 27
Hopkinson N S, Tennant R C, Dayer M J et al..
A prospective study of decline in fat free mass and skeletal muscle strength in chronic
obstructive pulmonary disease.
Respir Res.
2007;
8
25
- 28
Pitta F, Troosters T, Probst V S, Spruit M A, Decramer M, Gosselink R.
Physical activity and hospitalization for exacerbation of COPD.
Chest.
2006;
129
536-544
- 29
Garcia-Aymerich J, Farrero E, Félez M A, Izquierdo J, Marrades R M, Antó J M. Estudi
del Factors de Risc d’Agudització de la MPOC investigators .
Risk factors of readmission to hospital for a COPD exacerbation: a prospective study.
Thorax.
2003;
58
100-105
- 30
Garcia-Aymerich J, Lange P, Benet M, Schnohr P, Antó J M.
Regular physical activity reduces hospital admission and mortality in chronic obstructive
pulmonary disease: a population based cohort study.
Thorax.
2006;
61
772-778
- 31
Decramer M, Gosselink R, Troosters T, Verschueren M, Evers G.
Muscle weakness is related to utilization of health care resources in COPD patients.
Eur Respir J.
1997;
10
417-423
- 32
Kim S, Emerman C L, Cydulka R K, Rowe B H, Clark S, Camargo C A. MARC Investigators
.
Prospective multicenter study of relapse following emergency department treatment
of COPD exacerbation.
Chest.
2004;
125
473-481
- 33
Spencer S, Jones P W. GLOBE Study Group .
Time course of recovery of health status following an infective exacerbation of chronic
bronchitis.
Thorax.
2003;
58
589-593
- 34
Donaldson G C, Wilkinson T MA, Hurst J R, Perera W R, Wedzicha J A.
Exacerbations and time spent outdoors in chronic obstructive pulmonary disease.
Am J Respir Crit Care Med.
2005;
171
446-452
- 35
Puhan M A, Scharplatz M, Troosters T, Steurer J.
Respiratory rehabilitation after acute exacerbation of COPD may reduce risk for readmission
and mortality: a systematic review.
Respir Res.
2005;
6
54
- 36
Puhan M A, Scharplatz M, Troosters T, Walters E H, Steurer J.
Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary
disease.
Cochrane Database Syst Rev.
2009;
(1)
CD005305
- 37
Behnke M, Taube C, Kirsten D, Lehnigk B, Jörres R A, Magnussen H.
Home-based exercise is capable of preserving hospital-based improvements in severe
chronic obstructive pulmonary disease.
Respir Med.
2000;
94
1184-1191
- 38
Kirsten D K, Taube C, Lehnigk B, Jörres R A, Magnussen H.
Exercise training improves recovery in patients with COPD after an acute exacerbation.
Respir Med.
1998;
92
1191-1198
- 39
Man W D, Polkey M I, Donaldson N, Gray B J, Moxham J.
Community pulmonary rehabilitation after hospitalisation for acute exacerbations of
chronic obstructive pulmonary disease: randomised controlled study.
BMJ.
2004;
329
1209
- 40
Murphy N, Bell C, Costello R W.
Extending a home from hospital care programme for COPD exacerbations to include pulmonary
rehabilitation.
Respir Med.
2005;
99
1297-1302
- 41
Nava S.
Rehabilitation of patients admitted to a respiratory intensive care unit.
Arch Phys Med Rehabil.
1998;
79
849-854
- 42
Hawkins P, Johnson L C, Nikoletou D et al..
Proportional assist ventilation as an aid to exercise training in severe chronic obstructive
pulmonary disease.
Thorax.
2002;
57
853-859
- 43
Keilty S E, Ponte J, Fleming T A, Moxham J.
Effect of inspiratory pressure support on exercise tolerance and breathlessness in
patients with severe stable chronic obstructive pulmonary disease.
Thorax.
1994;
49
990-994
- 44
Maltais F, Reissmann H, Gottfried S B.
Pressure support reduces inspiratory effort and dyspnea during exercise in chronic
airflow obstruction.
Am J Respir Crit Care Med.
1995;
151
1027-1033
- 45
van ’t Hul A, Gosselink R, Hollander P, Postmus P, Kwakkel G.
Training with inspiratory pressure support in patients with severe COPD.
Eur Respir J.
2006;
27
65-72
- 46
Probst V S, Troosters T, Celi S G.
Effects of resistance training during hospitalisation due to an acute exacerbation
of COPD preliminary results [abstract].
Eur Respir J (suppl).
2005;
- 47
Probst V S, Troosters T, Coosemans I et al..
Mechanisms of improvement in exercise capacity using a rollator in patients with COPD.
Chest.
2004;
126
1102-1107
- 48
Beckerman M, Magadle R, Weiner M, Weiner P.
The effects of 1 year of specific inspiratory muscle training in patients with COPD.
Chest.
2005;
128
3177-3182
- 49
Sánchez Riera H, Montemayor Rubio T, Ortega Ruiz F et al..
Inspiratory muscle training in patients with COPD: effect on dyspnea, exercise performance,
and quality of life.
Chest.
2001;
120
748-756
- 50
Magadle R, McConnell A K, Beckerman M, Weiner P.
Inspiratory muscle training in pulmonary rehabilitation program in COPD patients.
Respir Med.
2007;
101
1500-1505
- 51
Hill K, Jenkins S C, Philippe D L et al..
High-intensity inspiratory muscle training in COPD.
Eur Respir J.
2006;
27
1119-1128
Christine MikelsonsM.Sc.
Physiotherapy Department, Royal Free Hospital, Pond Street
London, NW3 2QG, UK
Email: christine.mikelsons@royalfree.nhs.uk