In Vitro Anti-influenza Viral Activities of Stilbenoids from the Lianas of Gnetum pendulum

Abstract

The anti-influenza viral activities of six stilbenoids from the lianas of Gnetum pendulum C. Y. Cheng were evaluated with two different assays, neuraminidase (NA) activity assay and cytopathic effect (CPE) reduction assay. The NA assay results showed that all six stilbenoids exerted an NA inhibitory effect, while the CPE assay indicated that among them, isorhapontigenin (2), gnetupendin B (3), shegansu B (4), and gnetin D (6) exhibit significant in vitro anti-influenza viral activity in MDCK cells, with IC₅₀ values from 0.67 to 11.99 µg/mL in comparison to the positive controls oseltamivir acid and ribavirin whose IC₅₀ values were 0.040 and 5.54 µg/mL, respectively.

Key words

Gnetum pendulum - Gnetaceae - influenza virus - neuraminidase - stilbenoid

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