Abstract
The quality assessment and control of traditional Chinese medicines (TCM) nowadays
receives a great deal of attention worldwide and particularly in Europe with its increasing
local use. Polygonum cuspidatum Siebold & Zucc. and Polygonum multiflorum Thunb. are two members of the Polygonaceae family, which are widely used as Chinese
medicinal plants. The aim of this study was to achieve an overview of the quality
of P. cuspidatum and P. multiflorum samples available on the Chinese market and to identify important metabolites for
their discrimination, using 1H NMR-based metabolomics. 1H NMR and multivariate analysis techniques were applied to almost 60 plant samples
collected in different places in China. Using 1H NMR metabolomics, it was possible, without previous evaporation or separation steps,
to obtain metabolic fingerprints to distinguish between the species. The important
metabolites for discrimination were stilbene derivatives. Finally, a clear distinction
between the two species was possible and the discriminant metabolites were identified.
Key words
metabolomics -
1H NMR -
Polygonum cuspidatum
-
Polygonum multiflorum
- Polygonaceae
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Dr. Michel Frédérich
Laboratory of Pharmacognosy
Drug Research Center (CIRM)
University of Liège
Avenue de l'Hôpital, 1, B36
4000 Liège
Belgium
Phone: + 32 43 66 43 31
Fax: + 32 43 66 43 32
Email: M.Frederich@ulg.ac.be
