Leakages at surgical anastomoses in the gastrointestinal tract represent a challenging
clinical problem. Standard therapy entails conservative or surgical revision of the
anastomotic area with high morbidity and mortality up to 30 %. None of the previous
endoscopic approaches, which include stenting, endoscopic clip closure, and fibrin
glue injection, are sufficiently established for routine clinical use. We report a
case of a 68-year-old woman with a postoperative leakage and abscess at the esophagojejunostomy.
The defect was closed with two anchor-lock sutures. The patient was able to resume
oral food intake 5 days later and made a full recovery with endoscopically documented
mucosal healing at the site of the anastomosis. In summary, endoscopic suturing may
be a promising approach for the treatment of postoperative leaks that warrants further,
controlled investigation.
References
- 1
Junemann-Ramirez M, Awan M Y, Khan Z M, Rahamim J S.
Anastomotic leakage post-esophagogastrectomy for esophageal carcinoma: retrospective
analysis of predictive factors, management and influence on longterm survival in a
high volume centre.
Eur J Cardiothorac Surg.
2005;
27
3-7
- 2
Whooley B P, Law S, Murthy S C. et al .
Analysis of reduced death and complication rates after esophageal resection.
Ann Surg.
2001;
233
338-344
- 3
Khan A Z, Nikolopolous I, Botha A J, Mason R C.
Substernal long segment left colon interposition for oesophageal replacement.
Surgeon.
2008;
6
54-56
- 4
Parekh K, Iannettoni M D.
Complications of esophageal resection and reconstruction.
Seminars in thoracic and cardiovascular surgery.
2007;
19
79-88
- 5
Mariette C, Piessen G, Balon J M. et al .
Surgery alone in the curative treatment of localised oesophageal carcinoma.
Eur J Surg Oncol.
2004;
30
869-876
- 6
Mariette C, Taillier G, Van Seuningen I, Triboulet J P.
Factors affecting postoperative course and survival after en bloc resection for esophageal
carcinoma.
Ann Thorac Surg.
2004;
78
1177-1183
- 7
Matory Y L, Burt M.
Esophagogastrectomy: reoperation for complications.
J Surg Oncol.
1993;
54
29-33
- 8
Pennathur A, Luketich J D.
Resection for esophageal cancer: strategies for optimal management.
Ann Thorac Surg.
2008;
85
751-756
- 9
Rodella L, Laterza E, De Manzoni G. et al .
Endoscopic clipping of anastomotic leakages in esophagogastric surgery.
Endoscopy.
1998;
30
453-456
- 10
Infante M, Valente M, Andreani S. et al .
Conservative management of esophageal leaks by transluminal endoscopic drainage of
the mediastinum or pleural space.
Surgery.
1996;
119
46-50
- 11
Adler D G, McAfee M, Gostout C J.
Closure of an esophagopleural fistula by using fistula tract coagulation and an endoscopic
suturing device.
Gastrointest Endosc.
2001;
54
652-653
- 12
Roy-Choudhury S H, Nicholson A A, Wedgwood K R. et al .
Symptomatic malignant gastroesophageal anastomotic leak: management with covered metallic
esophageal stents.
AJR Am J Roentgenol.
2001;
176
161-165
- 13
Doniec J M, Schniewind B, Kahlke V. et al .
Therapy of anastomotic leaks by means of covered self-expanding metallic stents after
esophagogastrectomy.
Endoscopy.
2003;
35
652-658
- 14
Tuebergen D, Rijcken E, Mennigen R. et al .
Treatment of thoracic esophageal anastomotic leaks and esophageal perforations with
endoluminal stents: efficacy and current limitations.
J Gastrointest Surg.
2008;
12
1168-1176
- 15
Peters J H, Craanen M E, van der Peet D L. et al .
Self-expanding metal stents for the treatment of intrathoracic esophageal anastomotic
leaks following esophagectomy.
Am J Gastroenterol.
2006;
101
1393-1395
- 16
Page R D, Shackcloth M J, Russell G N, Pennefather S H.
Surgical treatment of anastomotic leaks after oesophagectomy.
Eur J Cardiothorac Surg.
2005;
27
337-343
- 17
Truong S, Bohm G, Klinge U. et al .
Results after endoscopic treatment of postoperative upper gastrointestinal fistulas
and leaks using combined Vicryl plug and fibrin glue.
Surg Endosc.
2004;
18
1105-1108
- 18
Landen S, El Nakadi I.
Minimally invasive approach to Boerhaave’s syndrome: a pilot study of three cases.
Surg Endosc.
2002;
16
1354-1357
- 19
Fritscher-Ravens A, Cuming T, Jacobsen B. et al .
Feasibility and safety of endoscopic full-thickness esophageal wall resection and
defect closure: a prospective long-term survival animal study.
Gastrointest Endosc.
2009;
69
1314-1320
- 20
Raju G S, Fritscher-Ravens A, Rothstein R I. et al .
Endoscopic closure of colon perforation compared to surgery in a porcine model: a
randomized controlled trial (with videos).
Gastrointest Endosc.
2008;
68
324-332
- 21
Ikeda K, Fritscher-Ravens A, Mosse C A. et al .
Endoscopic full-thickness resection with sutured closure in a porcine model.
Gastrointest Endosc.
2005;
62
122-129
- 22
Fritscher-Ravens A, Patel K, Ghanbari A. et al .
Natural orifice transluminal endoscopic surgery (NOTES) in the mediastinum: long-term
survival animal experiments in transesophageal access, including minor surgical procedures.
Endoscopy.
2007;
39
870-875
1 J.H. and B.S. contributed equally to this paper.
A. Fritscher-RavensMD
Department of Internal Medicine I
University Hospital Schleswig-Holstein, Campus Kiel
Schittenhelmstrasse 12
24105 Kiel
Germany
Fax: +49-431-5971302
eMail: fri.rav@btopenworld.com