Endoscopy 2011; 43(8): 664-670
DOI: 10.1055/s-0030-1256413
Original article

© Georg Thieme Verlag KG Stuttgart · New York

Endoscopic submucosal dissection in a European setting. A multi-institutional report of a technique in development

S.  Farhat1 , S.  Chaussade1 , 2 , T.  Ponchon3 , D.  Coumaros4 , A.  Charachon5 , T.  Barrioz6 , S.  Koch7 , P.  Houcke8 , C.  Cellier9 , D.  Heresbach10 , V.  Lepilliez3 , B.  Napoleon11 , P.  Bauret12 , E.  Coron13 , M.  Le Rhun13 , P.  Bichard14 , E.  Vaillant8 , A.  Calazel15 , E.  Bensoussan16 , S.  Bellon17 , L.  Mangialavori1 , F.  Robin18 , F.  Prat1 , 2 and the SFED ESD study group
  • 1Hôpital Cochin, Paris
  • 2Université Paris Descartes, Paris
  • 3Hôpital Edouard Herriot, Lyon
  • 4CHU Strasbourg
  • 5Hôpital Henri Mondor, Créteil
  • 6CHU Poitiers
  • 7CHU Besançon
  • 8Centre médical du Nord, Lille
  • 9Hôpital Européen Georges Pompidou, Paris
  • 10CHU Rennes
  • 11HP Jean Mermoz, Lyon
  • 12Clinique Beausoleil, Montpellier
  • 13CHU Nantes
  • 14CHU Grenoble
  • 15Polyclinique du Parc, Toulouse
  • 16Clinique de l'Alma, Paris
  • 17CH Avignon
  • 18SFED (Société Française d'Endoscopie Digestive), Paris
Further Information

Publication History

submitted 13 August 2010

accepted after revision 2 March 2011

Publication Date:
27 May 2011 (online)

Background and study aims: Endoscopic submucosal dissection (ESD) is a technique for “en bloc” resection of superficial tumors of the gastrointestinal tract. In France, experience with this technique is still limited. We wanted to assess the development of ESD in France, with special attention to short term outcomes.

Patients and methods: Members of the Société Française d'Endoscopie Digestive (SFED) who declared performing ESD reported their cases prospectively on a voluntary basis. Demographic, clinical, and technical data, and the results of immediate complications were collected. Case reports were completed prospectively by each investigator before pooled analysis.

Results: A total of 188 consecutive case reports were collected from 16 centers. The median case mix per center was 6 patients (range 1 – 43). The lesion sites treated by ESD were the stomach (n = 75), esophagus (n = 27), duodenum (n = 1), cecum (n = 2), right colon (n = 3), transverse colon (n = 5), sigmoid (n = 3), and rectum (n = 72). The median size of the lesions was 26 mm (range 2 – 150 mm). En bloc resection was achieved in 77.1 % of cases, with complete R0 resection in 72.9 %. Histopathology results showed high grade dysplasia or superficial cancer in 71.2 %. The median duration of ESD was 105 minutes (range 20 – 450 minutes). The short term morbidity was 29.2 % including 34 cases of perforation (18.1 %), and 21 hemorrhages (11.2 %) during the 24 hours following ESD, 89 % of which were managed conservatively or endoscopically.

Conclusion: In this early experience, the feasibility of ESD appeared to be good but R0 resection and complication rates did not match those reported by Japanese authors and must be improved by an extended practice.

References

F. Prat, MD, PhD 

Hôpital Cochin
Endoscopy Unit
Gastroenterology Dept.
Pavillon Achard

27 rue du faubourg St Jacques
75014 Paris
France

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Email: [email protected]