Download PDF
Synfacts 2010(8): 0855-0855  
DOI: 10.1055/s-0030-1257766
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of ent-Abudinol B

Contributor(s): Steven V. Ley, Philippa B. Cranwell
M. A. Boone, R. Tong, F. E. McDonald*, S. Lense, R. Cao, K. I. Hardcastle
Emory University, Atlanta, USA
Further Information

Publication History

Publication Date:
22 July 2010 (online)

    Permissions and Reprints

Significance

Abudinol B was isolated from the sea sponge Ptilocaulis spiculifer. Abudinol B does not display any useful biological activity, but its unusual architecture renders it an interesting target. It is proposed that natural abudinol B is made from polycyclizations of squalene tetraepoxide ­involving two different cascade cyclization events.