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Synfacts 2010(8): 0884-0884  
DOI: 10.1055/s-0030-1257838
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

Incorporation of π-Conjugated Molecules within Peptide Backbones

Contributor(s): Timothy M. Swager, William R. Collins
G. S. Vadehra, B. D. Wall, S. R. Diegelmann, J. D. Tovar*
Johns Hopkins University, Baltimore, USA
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Publication History

Publication Date:
22 July 2010 (online)

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Significance

The authors demonstrate a concise method for the preparation of π-conjugated molecules within a peptide backbone. Utilizing Fmoc-deprotected, resin-immobilized peptide se­quences, conjugated diacids or conjugated dianhydrides could be transformed into the diamide or diimide. After cleavage of the peptide sequence from the resin the dipeptide-bound conjugated molecule can be isolated. This approach allows for specific N-to-C peptide polarity extending from the conjugated molecule.