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Synfacts 2010(9): 1020-1020  
DOI: 10.1055/s-0030-1257945
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Platinum-Catalyzed Asymmetric [3+2] Cycloadditions of Carbonyl Ylides

Contributor(s): Mark Lautens, Stephen G. Newman
K. Ishida, H. Kusama, N. Iwasawa*
Tokyo Institute of Technology, Japan
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Publication History

Publication Date:
23 August 2010 (online)

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Significance

Transition-metal-catalyzed cyclo­additions are attractive due to their atom economy and ability to form multiple bonds in a single transformation. Enantioselective variants are particularly useful as multiple stereocenters can be generated from achiral starting materials. Extending on previous racemic work (Angew. Chem. Int. Ed. 2008, 47, 4903), the authors present an enantio­selective platinum(II)-catalyzed domino alkyne activation followed by a [3+2] cycloaddition.