Abstract
Reactions of 2,4,5-trimethyloxazole, 2,4,5-trimethylthiazole,
2-methylthiazole, and 2-ethyl-4,5-dimethylthiazole with different
acid chlorides in the presence of different bases were explored.
Arylvinyl esters of substituted benzoic acids containing substituted
oxazoles or thiazoles were formed when aroyl chlorides were used.
Degrees of aroylation were different with different bases. Reactions
with alkyl acid chlorides were also explored. Most of these reactions
occurred through cyclic ketene acetal intermediates.
Key words
carbon-carbon bond formation - oxazoles - thiazoles - vinyl esters - in situ generated
cyclic ketene acetal
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