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Synfacts 2011(1): 0003-0003  
DOI: 10.1055/s-0030-1258976
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of PRC200-SS

Contributor(s): Philip Kocienski
P. Valenta, P. J. Carroll, P. J. Walsh*
University of Pennsylvania, Philadelphia, USA
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Publication History

Publication Date:
21 December 2010 (online)

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Significance

PRC200-SS is a serotonin-norepinephrine-dopamine reuptake inhibitor and a lead compound for the treatment of depression. This short and efficient synthesis of PRC200-SS features the asymmetric addition of the β-amino ­alkenyl zinc reagent D to benzaldehyde in the presence of the chiral chaperone E.