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Synthesis of Oseltamivir
J. S. Ko, J. E. Keum, S. Y. Ko*
Ewha Womans University, Seoul, Korea
21 December 2010 (online)
Oseltamivir is an orally active neuraminidase inhibitor prescribed for the treatment of various influenzas. The key step in this small-scale, 16-step synthesis (7.1% overall from d-mannitol) is the intramolecular aldol reaction of lactone E to give the bicyclic derivative F in 76% yield as a single diastereoisomer.