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Stereoselective [3+2] Cycloaddition of Imino Esters with Nitroalkenes
T. Arai*, N. Yokoyama, A. Mishiro, H. Sato
Chiba University and Rigaku Corporation, Tokyo, Japan
21 December 2010 (online)
A library of solid-phase imidazoline-aminophenol/metal catalysts was prepared and a high-throughput screening method employing analysis by circular dichroism spectroscopy was used to find the most selective catalyst. This is the first method to generate exo′ products in high diastereoselectivity and with excellent ee values.