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Modification of BINAP Ligand has Profound Effect in Intramolecular Heck Reactions
D. A. Rankic, D. Lucciola, B. A. Keay*
University of Calgary, Canada
21 December 2010 (online)
The BINAP ligand was modified at the 3,3′- and the P-positions. The modifications had a pronounced impact on enantioselectivity of some previously reported intramolecular Heck reactions with increased asymmetric induction observed in a number of cases.