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Synthesis of Chiral α,β-Diamino Acids Using Copper(I)/TF-BiphamPhos
G. Liang, M.-C. Tong, H. Tao, C.-J. Wang*
Wuhan University, P. R. of China
21 December 2010 (online)
Having previously developed a chiral copper(I)/TF-BiphamPhos complex, the authors apply this catalyst to the Mannich reaction of N-tosylimines with a glycine-derived Schiff base. The chiral α,β-diamino acids synthesized are key biological compounds and synthetic building blocks in organic synthesis.