Synfacts 2011(1): 0086-0086  
DOI: 10.1055/s-0030-1259121
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Substitution of Silanes with Grignard Reagents

Contributor(s): Paul Knochel, Thomas Kunz
N. Hirone, H. Sanjiki, R. Tanaka, T. Hata, H. Urabe*
Tokyo Institute of Technology Yokohama, Japan
Further Information

Publication History

Publication Date:
21 December 2010 (online)


A practical substitution reaction of silanes with Grignard reagents in the presence of lithium chloride is described. The reaction rate of allyl and aryl Grignard reagents is greatly accelerated. For many examples, LiCl can be used only in catalytic amounts (5 mol%). Even inherently less reactive alkylsilanes and sterically demanding Grignard reagents give excellent yields.