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Substitution of Silanes with Grignard Reagents
N. Hirone, H. Sanjiki, R. Tanaka, T. Hata, H. Urabe*
Tokyo Institute of Technology Yokohama, Japan
21 December 2010 (online)
A practical substitution reaction of silanes with Grignard reagents in the presence of lithium chloride is described. The reaction rate of allyl and aryl Grignard reagents is greatly accelerated. For many examples, LiCl can be used only in catalytic amounts (5 mol%). Even inherently less reactive alkylsilanes and sterically demanding Grignard reagents give excellent yields.