Synfacts 2011(1): 0065-0065  
DOI: 10.1055/s-0030-1259167
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Rhodium-Catalyzed Domino C-H Activation-Intramolecular Allylation of Imines

Contributor(s): Mark Lautens, Stephen G. Newman
D. N. Tran, N. Cramer*
ETH Zürich, Switzerland
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21. Dezember 2010 (online)


The authors report the use of aryl ketimines to both direct a metal for C-H activation and subsequently act as an electrophile. This rhodium-catalyzed domino process forms complex indane products from simple starting materials.