Synfacts 2011(1): 0045-0045  
DOI: 10.1055/s-0030-1259170
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Propargylation of Benzaldehydes

Contributor(s): Mark Lautens, Stephen G. Newman
D. L. Usanov, H. Yamamoto*
The University of Chicago, USA
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21. Dezember 2010 (online)


The catalytic asymmetric Nozaki-Hiyama (NH) reaction provides direct access to useful chiral alcohols. Utilizing a novel chiral chromium catalyst, the authors report an efficient enantioselective propargylation of benzaldehyde derivatives, providing chiral homopropargyl alcohols with good yields and enantioselectivities.