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Enantioselective Cycloaddition of Nitrones with Propioloyl- and Acryloylpyrazoles
A. Sakakura, M. Hori, M. Fushimi, K. Ishihara*
Nagoya University, Japan
21 December 2010 (online)
The authors describe an enantioselective dipolar cycloaddition of nitrones and electon-deficient alkenes and alkynes. This work follows the authors’ work on the asymmetric Diels-Alder reaction using similar alanine-derived chiral ligands (J. Am. Chem. Soc. 2008, 130, 7532). The enantioselectivities are generally good for both alkene and alkyne dienophiles.
Review: L. M. Stanley, M. P. Sibi Chem. Rev. 2008, 108, 2887-2902.