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Synfacts 2011(3): 0246-0246
DOI: 10.1055/s-0030-1259408
DOI: 10.1055/s-0030-1259408
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Streptolydigin
S. V. Pronin, S. A. Kozmin*
The University of Chicago, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
16. Februar 2011 (online)
Significance
Streptolydigin is a highly potent broad-spectrum antibiotic isolated from Streptomyces lydicus. It displays inhibitory activity against bacterial RNA polymerase with a distinct mode of action compared with the rifamycins that are commonly used to treat tuberculosis.