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Synfacts 2011(3): 0346-0346
DOI: 10.1055/s-0030-1259468
DOI: 10.1055/s-0030-1259468
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
One-Pot N-Alkylation of Amine with Alcohols Using Au/TiO2-VS
L. He, X.-B. Lou, J. Ni, Y.-M. Liu, Y. Cao*, H.-Y. He, K.-N. Fan
Fudan University, Shanghai, P. R. of China
Further Information
Publication History
Publication Date:
16 February 2011 (online)
Significance
Titania-supported gold nanoparticles (Au/TiO2-VS, 1) were prepared and applied to the one-pot N-alkylation of amines with alcohols. Thus, nanocomposite 1 with an average size of 1.8 nm was obtained in three steps. The one-pot N-alkylation reaction of aniline 2a with benzyl alcohol 3a was carried out in the presence of Au/TiO2-SV 1 (0.5 mol% Au) to give 92% yield of N-benzylaniline (4a).