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Stereoselective Synthesis of Substituted Piperidin-4-ols
L. Cui, C. Li, L. Zhang*
University of California, Santa Barbara, USA
16 February 2011 (online)
The piperidine core is an important substructure, which can be found in various natural products and medicinally relevant molecules. Due to this fact the development of selective and modular synthetic methods towards the piperidine scaffold is a desirable task. This paper presents a one-pot synthesis of piperidin-4-ols 2 starting from readily available N-homopropargyl amides of type 1 in high yields and good to excellent diastereoselectivities.