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Synfacts 2011(3): 0280-0280  
DOI: 10.1055/s-0030-1259496
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Construction of α-Trifluoro-methyl-Substituted Tertiary Alcohols

Contributor(s): Hisashi Yamamoto, Zhi Li
K. Aikawa, Y. Hioki, K. Mikami*
Tokyo Institute of Technology, Japan
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Publication History

Publication Date:
16 February 2011 (online)

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Significance

The authors introduce a chiral pal­ladium catalyst system that enables the highly enantioselective construction of chiral tertiary alcohols bearing a trifluoromethyl group, an ethoxycarbonyl group, and an alkynyl group as substituents. The starting materials are trifluoropyruvate and the corresponding alkynylsilanes.