Synlett 2021(4): 462-463  
DOI: 10.1055/s-0030-1259544
CLUSTER
© Georg Thieme Verlag Stuttgart ˙ New York

Cluster Preface: Challenges of Proline-Based Aminocatalysis

Benjamin List*
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany
Fax: +49(208)3062982; e-Mail: list@mpi-muelheim.mpg.de;
Further Information

Publication History

Received 12 January 2011
Publication Date:
16 February 2011 (online)

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Abstract

During the last eleven years, aminocatalysis, the catalysis of carbonyl transformations via iminium ion and enamine intermediates has become a highly successful and general approach to asymmetric synthesis. There are now several dozens of different ­reaction types with hundreds of variants that are mediated by primary and secondary amine catalysts, of which proline continues to be a privileged motif. This Cluster highlights recent attempts towards solving some of the remaining challenges in the area.

Key words

proline - aminocatalysis - enamine catalysis - iminium ion catalysis

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