Synfacts 2011(4): 0358-0358  
DOI: 10.1055/s-0030-1259593
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of MK-3281

Contributor(s): Philip Kocienski
F. Narjes et al.*
Merck Research Laboratories, Rome, Italy and Ghent University Hospital, Belgium
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18. März 2011 (online)


RNA polymerase NS5B plays a key role in the life cycle of the hepatitis C virus. MK-3281 binds to the thumb domain of RNA polymerase NS5B, thereby preventing replication of the viral genome.