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Synfacts 2011(4): 0398-0398  
DOI: 10.1055/s-0030-1259647
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Synthesis of Alkynylcyclopropanes

Contributor(s): Mark Lautens, Stephen G. Newman
A. Tenaglia*, K. Le Jeune, L. Giordano, G. Buono
Université Aix-Marseille, France
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Publication History

Publication Date:
18 March 2011 (online)

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Significance

Cyclopropanes are found in a wide variety of natural products and serve as useful precursors for the synthesis of complex molecules (see Review below). The authors present a palladium-catalyzed synthesis of alkynylcyclopropanes by addition of alkynes across cyclopropenes.

Review: W. A. Donaldson Tetrahedron 2001, 57, 8589-8627.