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Enantioselective Conjugated Addition of Vinylaluminums to Cyclic Enones
T. L. May, J. A. Dabrowski, A. H. Hoveyda*
Boston College, Chestnut Hill, USA
18 March 2011 (online)
The development of transition-metal-catalyzed enantioselective reactions allowing the formation of quaternary stereogenic centers is a challenging task. Herein, the authors report a highly enantioselective conjugated addition of Si-substituted vinylaluminum reagents to five- and six-membered cyclic β-substituted enones of type 1. A chiral bidentate NHC-copper complex has been identified to facilitate the desired transformation of 1 into 2 with good to excellent yields and enantioselectivities.