Synfacts 2011(4): 0408-0408  
DOI: 10.1055/s-0030-1259662
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Chiral Aminotriazole Ligands in Ruthenium-Catalyzed Transfer Hydrogenation

Contributor(s): Hisashi Yamamoto, Zhi Li
X. C. Cambeiro, M. A. Pericàs*
Institute of Chemical Research of Catalonia, Tarragona and Universitat de Barcelona, Spain
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18. März 2011 (online)


This paper describes the preparation and catalytic performance of a new class of chiral aminotriazole ligands. In order to examine the catalytic performance of these new ligands, synthesized from copper-catalyzed click chemistry, they are applied in the ruthenium-catalyzed asymmetric transfer hydrogenation of ketones and good results are obtained after careful optimization.