Synthesis 2011(11): 1733-1740  
DOI: 10.1055/s-0030-1260047
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Facile Synthesis of 6H-[1,3,5]Triazino[2,1-b]quinazolin-6-ones

Shaun Abbott, Josée Cloutier, Karine Houde, Christopher Penney, Boulos Zacharie*
ProMetic BioSciences Inc., 500 boulevard Cartier Ouest, Bureau 150, Laval, QC, H7V 5B7, Canada
Fax: +1(450)7811403; e-Mail: b.zacharie@prometic.com;
Further Information

Publication History

Received 7 January 2011
Publication Date:
13 May 2011 (online)

Abstract

Triazinoquinazolinone derivatives are synthesized by cyclization of aminobenzamide-substituted triazine compounds in the presence of a proton source such as trifluoroacetic acid or hydrochloric acid. The reaction is mild, general, and gives high yield (>90%) of the cyclized product. This procedure allows, for the first time, access to triazinoquinazolinone compounds bearing different functionalities on the benzene and triazine moieties that are not available by other routes.

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