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Enantioselective Propargylic Amination of Nonaromatic Propargylic Esters
A. Yoshida, G. Hattori, Y. Miyake, Y. Nishibayashi*
The University of Tokyo, Japan
20 July 2011 (online)
This paper expands the scope of suitable substrates for the enantioselective substitution onto propargyl alcohol derivatives bearing an alkyl group (cyclic or acyclic) at the propargylic position; this was achieved by replacing the common acetate leaving group by pentafluorobenzoate. A number of products were obtained with moderate yields (40-60%) and high enantioselectivities (77-90% ee).