Brønsted Acid Catalyzed Synthesis of Spirooxindole Pyrans
J. Wang, E. A. Crane, K. A. Scheidt*
Northwestern University, Evanston, USA
19. August 2011 (online)
The authors report a synthesis of spirooxindole pyrans through a Brønsted acid catalyzed Prins cyclization. The reaction is highly diastereoselective and the products comprise an important structural motif. Several reactions of the products are reported to yield a variety of interesting derivatives.