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Synfacts 2011(10): 1115-1115
DOI: 10.1055/s-0030-1261077
DOI: 10.1055/s-0030-1261077
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Regioselective Oxidative Couplings of 3-Substituted Thiophenes
I. Schnapperelle, S. Breitenlechner*, T. Bach*
Technische Universität München, Garching, Germany
Further Information
Publication History
Publication Date:
20 September 2011 (online)
Significance
This work discloses the oxidative coupling of different arylboronic acids at the C4 position of 3-substituted thiophenes. High regioselectivities are achieved regarding substitution at C4 vs. C2- or C5-substitution. Due to elevated stability under oxidative conditions, the phosphonates lead to superior product yields than the acetate-substituted thiophenes.