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Synfacts 2011(10): 1053-1053
DOI: 10.1055/s-0030-1261100
DOI: 10.1055/s-0030-1261100
Synthesis of Heterocycles
© Georg Thieme Verlag
Stuttgart ˙ New York
Pd-Catalyzed Synthesis of 1,4-Dihydro-pyridines via a Multicomponent Reaction
H. Jiang*, X. Ji, Y. Li, Z. Chen, A. Wang
South China University of Technology, Guangzhou, P. R. of China
Further Information
Publication History
Publication Date:
20 September 2011 (online)
Significance
A Pd-catalyzed three-component synthesis of 1,4-dihydropyridines is described. Starting from simple or easily available aromatic aldehydes, aryl amines and terminal olefins, the reaction proceeds smoothly under mild conditions and an O2 atmosphere to afford 2,6-unsubstituted 1,4-dihydropyridines in moderate to good yields. The process constitutes an efficient modified Hantzsch reaction. However, the reaction yields were greatly decreased when the process was conducted in laboratory air or at a lower temperature.