Zusammenfassung
Der Einsatz von Pflanzenextrakten bei Wechseljahresbeschwerden hat zunehmend an Bedeutung
gewonnen, wobei die Mehrzahl der Extrakte (Rotklee, Hopfen, Soja und daraus gewonnene
Isoflavonpräparate) ihre Wirkungen, zumindest teilweise, über die Bindung an Östrogenrezeptoren
erreichen. Die klinische Relevanz dieser Extrakte (»Phytoöstrogene«) ist nicht unumstritten.
Wegen der Aktivierung von Östrogenrezeptoren kann mit ihrem Einsatz die Stimulation
östrogensensitiver Geschwülste erfolgen. Abgegrenzt von der Gruppe der Phytoöstrogene
ist der Extrakt aus Cimicifuga racemosa zu bewerten. Seine Wirkungen auf die psychischen und vegetativen Befindlichkeiten
während der Wechseljahre sind klinisch belegt; sie werden überwiegend über das Zentralnervensystem
vermittelt. Durch Östrogen stimuliertes Tumorwachstum wird sogar unterdrückt. Eine
mit der klinischen Wirksamkeit verbundene Inhaltsstoffgruppe sind Triterpenglykoside.
Es gibt Hinweise, dass mit einer Erhöhung des Gehalts an Triterpenglykosiden im Extrakt
auch dessen klinische Wirksamkeit gesteigert wird.
Summary
Preparations from Cimicifuga racemosa for alternative treatment of menopausal complaints
The period of menopause is characterized by hormonal changes in the female body. The
related complaints are temporary and in the most cases therapeutic intervention is
not necessary. If the complaints are however heavy, a hormone replacement therapy
might be an option. But such kind of therapy should be timely limited. Another option
is the administration of psychoactive substances, especially anti-depressives. Herbs
have gained increasing attention for treatment of menopausal complaints. Most of them
(e.g. red clover, hops, soya, and their special preparations) activate, at least partially,
oestrogen receptors. The clinical relevance of these herbs, which are summarized as
phytoestrogens, is not unequivocal. Activation of the oestrogen receptors might induce
growth of hormone sensitive tumours. Beside phytoestrogens, extracts prepared form
Cimicifuga racemosa L. (black cohosh) are clinically effective. This effectiveness is mediated by central
nervous processes and not by stimulation of the oestrogen receptors. In fact even
oestrogen stimulated tumour growth becomes effectively inhibited by black cohosh extracts.
The clinically proven efficacy to overcome psychological and vegetative complaints
related to menopause is generally accepted. Triterpene glykosides are considered active
principles within the extract and there are hints, that the clinical efficacy will
be positively correlated with the content of the Triterpene glykosides.
Schlüsselwörter
Wechseljahre - alternative Behandlungen - Traubensilberkerze -
Cimicifuga racemosa (L.) Nutt. - Ranunculaceae - Triterpenglykoside
Key words
Cimicifuga racemosa (L.) Nutt. - black cohosh - menopausal complaints - alternative treatment
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Prof. Dr. Axel Brattström
Alexander Puschkin Str. 50
39108 Magdeburg
Email: Axel.Brattstroem@t-online.de
Online
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