Selektive Estrogenrezeptor-Modulatoren (SERMs)

Zusammenfassung

Selektive Estrogenrezeptor-Modulatoren (SERMs) haben organselektive östrogene und östrogen-antagonstische Effekte. Die klinisch am häufigsten verwendeten SERMs sind Tamoxifen und Raloxifen, die beide an der Brustdrüse und (leider auch) im Hypothalamus östrogen-antagonistisch wirken. Prophylaktisch eingenommen, hemmen beide Substanzen die Entwicklung von Mammakarzinomen und einer Osteoporose. Da sie auch im Hypothalamus antagonistische Wirkungen haben, steigern sie klimakterische Beschwerden. Ihre östrogen-agonistischen Wirkungen im Uterus sind ebenfalls negativ zu werten. Phytoöstrogen (Isoflavon)-haltige Soja- und Rotkleeprodukte haben in den empfohlenen Dosierungen kaum positive, aber vermutlich auch keine negativen Wirkungen. Extrakte aus der Traubensilberkerze enthalten keine Östrogene, hemmen aber über neurotransmitterähnliche Substanzen klimakterische Beschwerden.

Summary

Selective estrogen receptor modulators (SERMs) have organ specific estrogen and estrogen-antagonistic effects. The two most commonly used SERMs are Tamoxifen and Raloxifen, which have antiestrogenic effects in the mammary gland and (unfortunately also) in the hypothalamus. From a prophylactic view, both substances decrease the development of mammary cancer (which is due to their estrogen-antagonistic properties) and of osteoporosis (which is due to their estrogen-agonistic effects). Because of their estrogen-antagonistic effect in hypothalamus the vegetative climacteric symptoms are increased. Their estrogen-agonistic actions in uterus are clinically undesired. Phytoestrogens (Isoflavone)-containing soy- and red clover-products have in the daily recommended doses minor, if any positive but probably also no adverse effects. Cimicifuga racemosa extracts have no estrogenic effects but they ameliorate climacteric vegetative complaints due to neurotransmitter-like activities.

Schlüsselwörter

SERM - Phytoöstrogene - Soja - Rotklee - Cimicifuga - klimakterische Beschwerden

Key words

SERM - phytoestrogens - soy - red clover - black cohosh - climacteric complaints

Literatur

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Online

http://dx.doi.org/10.1055/s-0030-1262412