Horm Metab Res 2011; 43(1): 62-65
DOI: 10.1055/s-0030-1265221
Humans, Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Prolactin is Involved in the Systemic Inflammatory Response in Myocardial Infarction

A. Q. Reuwer1 , B. van Zaane1 , 2 , M. van Wissen2 , A. P. van Zanten3 , M. T. B. Twickler1 , V. E. A. Gerdes1 , 2
  • 1Department of Vascular Medicine of the Academic Medical Center, Amsterdam, The Netherlands
  • 2Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
  • 3Department of Clinical Biochemistry, Slotervaart Hospital, Amsterdam, The Netherlands
Further Information

Publication History

received 24.05.2010

accepted 31.08.2010

Publication Date:
30 September 2010 (online)


Prolactin may contribute to an atherogenic phenotype. Furthermore, previous studies have shown that prolactin levels increase in situations of acute stress and inflammation. We therefore aimed to investigate the relationship between prolactin, acute stress and inflammation in patients with myocardial infarction. We performed a case-control study in 40 patients with myocardial infarction and 39 controls, aged 41–84 years. Blood for assessment of prolactin and high sensitive C-reactive protein (hsCRP) was drawn at inclusion, that is, during the acute phase of the event, and 2–3 weeks later. Unexpectedly, prolactin levels at inclusion did not differ between cases and controls (7.0 ng/ml and 6.0 ng/ml, respectively, p=0.28). 2–3 weeks later prolactin levels in cases had not decreased. However, univariate regression analysis indicated that hsCRP is associated with prolactin levels (regression coefficient β 0.11; [95% CI 0.01; 0.21]; p=0.03) in cases during the acute phase of myocardial infarction. Our findings may suggest that prolactin is involved in the systemic inflammatory response, which takes place during myocardial infarction; however, this association may not be strong enough to induce higher prolactin levels in patients with myocardial infarction.



A. Q. Reuwer, MD 

Academic Medical Center

Department of Vascular


Meibergdreef 9

Room F4-145

1105 AZ Amsterdam

The Netherlands

Phone: +31/20/566 5975

Fax: +31/20/566 9343

Email: a.q.reuwer@amc.uva.nl